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Neuroscience 85:427–441ĭawson and Tricklebank MD (1995) Use of the elevated plus-maze in the search for novel anxiolytic agents. Neurochem Res 29:189-197ĭanober L, Pape HC (1998) Strychnine-sensitive glycine responses in neurons of the lateral amygdala: an electrophysiological and immunocytochemical characterization. Life Sci 73:3257–3264Įl Idrissi A, Trenkner E (2004) Taurine as a modulator of excitatory and inhibitory neurotransmission. Braz J Med Biol Res 38:1697–1701Ĭhen SW, Xin Q, Kong WX, Min L, Li JF (2003) Anxiolytic-like effect of succinic acid in mice. H, Viana MB (2005) The inactivation of the basolateral nucleus of the rat amygdala has an anxiolytic effect in the elevated T-maze and light/dark transition tests. Eur J Pharmacol 463:55–65īueno CH, Zangrossi Jr. Brain Res 692:57–65īourin M, Hascoet M (2003) The mouse light/dark box test. Behav Brain Res 125:141–149īenrabh H, Bourre JM, Lefauconnier JM (1995) Taurine transport at the blood-brain barrier: an in vivo brain perfusion study. Life Sci 17:669–678īelzung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviour in mice:a review. This process is experimental and the keywords may be updated as the learning algorithm improves.īarbeau A, Inoue N, Tsukada Y, Butterworth RF (1975) The neuropharmacology of taurine. These keywords were added by machine and not by the authors. Second, taurine when injected acutely had opposite effects than when administered chronically. The major findings of this are two folds: First these results suggest that taurine might play a role in the modulation of anxiety and locomotor activity. In the elevated arm maze, taurine injection suppressed anxiety whereas taurine supplementation was anxiogenic. We found that taurine supplementation induced an increase in the total distance traveled, the overall movement speed, the time the animals spent mobile, the number of line crossings, and the time the animals entered the center zone. In the open field test, taurine supplementation increased whereas taurine injection suppressed locomotor activity. We used two paradigms for taurine treatment: Acute injection versus chronic supplementation. These two test conditions generated different levels of anxiety, and both anxiolytic and anxiogenic effects of taurine could be assessed. In this study we investigated the effects of chronic versus acute taurine treatment on anxiety-like and locomotor behaviors using two behavioral tests: elevated plus-maze and open-field. We have previously reported that chronic supplementation of taurine in drinking water to mice increases brain excitability, mainly through alterations in the inhibitory GABAergic system.
#TAURINE ANXIETY FREE#
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It is beneficial to the body in numerous ways: Taurine is found naturally in seafood and meat. Taurine is an amino acid that supports neurological development and helps regulate the level of water and mineral salts in the blood.
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